Search publications
5 results for “NONO”
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Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
Cell chemical biology · 2026 · 33(2): 256-267.e11
RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We previously described a chloroacetamide compound (R)-SKBG-1 that covalently binds …
PMID 41534524 DOI ↗
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Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
bioRxiv : the preprint server for biology · 2025
RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We recently reported a chloroacetamide compound ( <i>R</i> )-SKBG-1 that …
PMID 40661397 DOI ↗
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Remodeling oncogenic transcriptomes by small molecules targeting NONO.
Nature chemical biology · 2023 · 19(7): 825-836
Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly and stereoselectively decrease the expression of transcripts encoding the androgen receptor and its splice variants …
PMID 36864190 DOI ↗
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Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Nucleic acids research · 2017 · 45(21): 12509-12528
To counteract the breakdown of genome integrity, eukaryotic cells have developed a network of surveillance pathways to prevent and resolve DNA damage. Recent data has recognized the importance of RNA binding proteins (RBPs) in DNA damage repair (DDR) pathways. Here, …
PMID 29069457 DOI ↗
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NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.
Nature structural & molecular biology · 2017 · 24(10): 816-824
MicroRNA (miRNA) biogenesis is known to be modulated by a variety of RNA-binding proteins (RBPs), but in most cases, individual RBPs appear to influence the processing of a small subset of target miRNAs. Here, we report that the RNA-binding NONO-PSF …
PMID 28846091 DOI ↗
Datasets 16
shRNA knockdown against NONO in HepG2 cells followed by RNA-seq. (NONO_BGHLV17)
Homo sapiens
shRNA knockdown against NONO in K562 cells followed by RNA-seq. (NONO_BGKLV19)
Homo sapiens
Remodeling of oncogenic transcriptomes by small-molecules targeting the RNA-binding protein NONO
Homo sapiens · GPL24676
Transcriptome changes in MCF7 cells after treatment with NONO ligands and controls
Homo sapiens · GPL20301
Remodeling oncogenic transcriptomes by small molecules targeting NONO
Homo sapiens · GPL20301
Transcriptome changes in 22Rv1 cells with a double knockout or over expression of C145S, Empty vector, or Wild type NONO.
Homo sapiens · GPL20301
The LncRNA NEAT1 Nests RNA Binding Proteins and the Microprocessor to Globally Enhance Pri-miRNA Processing
Homo sapiens · GPL20301
Transcriptome changes in 22Rv1 and MCF7 cells after treatment with NONO ligands and controls
Homo sapiens · GPL20301
Analyses 5
GSE299099 · 3 steps · RNA-Seq · code_examples
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO. (2026)
GSE198212 · 7 steps · RIP-Seq · code_examples
Remodeling oncogenic transcriptomes by small molecules targeting NONO. (2023)
GSE198419 · 7 steps · RNA-Seq · code_examples
Remodeling oncogenic transcriptomes by small molecules targeting NONO. (2023)
GSE222216 · 4 steps · RNA-Seq · code_examples
Remodeling oncogenic transcriptomes by small molecules targeting NONO. (2023)
GSE222217 · 7 steps · GSE · code_examples
Remodeling oncogenic transcriptomes by small molecules targeting NONO. (2023)