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4 results for “gut”
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Stratification of enterochromaffin cells by single-cell expression analysis.
eLife · 2025 · 12
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine to mediate disparate physiological responses. However, the molecular and cellular basis for …
PMID 40184163 DOI ↗
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Stratification of enterochromaffin cells by single-cell expression analysis.
bioRxiv : the preprint server for biology · 2025
Dynamic interactions between gut mucosal cells and the external environment are essential to maintain gut homeostasis. Enterochromaffin (EC) cells transduce both chemical and mechanical signals and produce 5-hydroxytryptamine (5-HT) to mediate disparate physiological responses. However, the molecular and cellular basis …
PMID 37662229 DOI ↗
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RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
Gut · 2022 · 71(9): 1790-1802
Tuft cells residing in the intestinal epithelium have diverse functions. In the small intestine, they provide protection against inflammation, combat against helminth and protist infections, and serve as entry portals for enteroviruses. In the colon, they had been implicated in …
PMID 34853057 DOI ↗
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Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses.
Science immunology · 2020 · 5(50)
Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We integrated single-cell RNA and antigen receptor sequencing to elucidate key components, cellular states, and clonal relationships of the peripheral and gastrointestinal …
PMID 32826341 DOI ↗
Datasets 6
Single-Cell Analyses Elucidate the Cellular and Molecular Landscape of Ulcerative Colitis
Homo sapiens · GPL20301
Transcriptome and cistrome analysis reveals synergistic roles for Sox9 and Pdx1 in lineage allocation of foregut progenitor cells
Mus musculus · GPL7202
MicroRNA expression data from differentiation of human H9 ESCs into definitive endoderm on MEF feeder layers
Homo sapiens · GPL8733
mRNA expression data from differentiation of human ESCs into definitive endoderm, Cyt49 on matrigel
Homo sapiens · GPL7363
MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm on MEF feeder layers
Homo sapiens · GPL8733
MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm in feeder-free conditions
Homo sapiens · GPL8733
Analyses 5
GSE61945 · 9 steps · RNA-Seq · code_examples
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. (2015)
GSE61946 · 9 steps · RNA-Seq · code_examples
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. (2015)
GSE61947 · 3 steps · ChIP-Seq · code_examples
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. (2015)
GSE61948 · 9 steps · GSE · code_examples
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. (2015)
GSE62023 · 5 steps · GSE · code_examples
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. (2015)