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3 results for “p53”
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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Molecular cell · 2020 · 80(3): 452-469.e9
Although TP53 is the most commonly mutated gene in human cancers, the p53-dependent transcriptional programs mediating tumor suppression remain incompletely understood. Here, to uncover critical components downstream of p53 in tumor suppression, we perform unbiased RNAi and CRISPR-Cas9-based genetic screens …
PMID 33157015 DOI ↗
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A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.
Scientific reports · 2019 · 9(1): 11071
AATF is a central regulator of the cellular outcome upon p53 activation, a finding that has primarily been attributed to its function as a transcription factor. Recent data showed that AATF is essential for ribosome biogenesis and plays a role …
PMID 31363146 DOI ↗
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Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism.
Nucleic acids research · 2017 · 45(21): 12509-12528
To counteract the breakdown of genome integrity, eukaryotic cells have developed a network of surveillance pathways to prevent and resolve DNA damage. Recent data has recognized the importance of RNA binding proteins (RBPs) in DNA damage repair (DDR) pathways. Here, …
PMID 29069457 DOI ↗
Datasets 11
Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage
Mus musculus · GPL9115
Transactivation-deficient p53 Mutants in Ras-induced Cellular Senescence
Mus musculus · GPL1261
Loss of canonical splicing factor SRSF1 in hepatocytes results in acute liver injury and regeneration
Mus musculus · GPL21103
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (RNA-seq NPC)
Mus musculus · GPL21103
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (RNA-seq e13invivo)
Mus musculus · GPL21103
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
Mus musculus · GPL21103
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size (scRNA-seq)
Mus musculus · GPL21103
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
Homo sapiens · GPL20301
Musashi1 is a master regulator of aberrant translation in Group 3 medulloblastoma
Homo sapiens · GPL20301
Nonsense-mediated mRNA decay counteracts TRP53 to maintain the progenitor cell pool for brain development (snRNA-seq_e15invivo)
Mus musculus · GPL21103
Analyses 13
GSE107122 · 4 steps · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE210437 · 9 steps · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE217735 · 2 steps · OTHER · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE220459 · 2 steps · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE220460 · 2 steps · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE220461 · 1 step · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE220462 · 2 steps · GSE · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE253825 · 1 step · RNA-Seq · code_examples
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size. (2024)
GSE145430 · 2 steps · RNA-Seq · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)
GSE14555 · 2 steps · GSE · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)
GSE27901 · 1 step · GSE · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)
GSE46240 · 5 steps · RNA-Seq · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)
GSE55727 · 5 steps · RNA-Seq · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)