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3 results for “insulin”

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  1. AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.

    Molecular cell · 2022 · 82(15): 2779-2796.e10

    Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Here, we describe a …

    PMID 35675814 DOI ↗

  2. A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.

    Genes & development · 2020 · 34(15-16): 1089-1105

    The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion within pancreatic …

    PMID 32616519 DOI ↗

  3. Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction.

    Circulation · 2020 · 142(4): 365-379

    Metabolic disorders such as obesity and diabetes mellitus can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than vascular endothelial growth …

    PMID 32393053 DOI ↗

Datasets 8

GSE68618 GSE · GEO

Aging-dependent demethylation of regulatory elements correlates with chromatin state and improved insulin secretion by pancreatic β cells

Mus musculus · GPL13112

GSE92602 GSE · GEO

Identification of islet-enriched long non-coding RNAs contributing to beta-cell failure in type 2 diabetes

Mus musculus · GPL9250

GSE69889 GSE · GEO

Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk

Mus musculus · GPL17021

GSE136908 GSE · GEO

RNA Seq of HMVEC under hypoxia

Homo sapiens · GPL11154

GSE136910 GSE · GEO

RNA Seq of Subcutaneous adipose tissue from endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates

Mus musculus · GPL13112

GSE157048 GSE · GEO

RNA-seq of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells

Mus musculus · GPL17021

GSE146916 GSE · GEO

A role for alternative splicing in circadian control of insulin secretion and glucose homeostasis

Mus musculus · GPL19057

GSE157050 GSE · GEO

Ribosome profiling of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells

Mus musculus · GPL17021

Analyses 3

GSE146916 Processing Pipeline

GSE146916 · 4 steps · RNA-Seq · code_examples

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. (2020)

GSE69889 Processing Pipeline

GSE69889 · 5 steps · RNA-Seq · code_examples

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. (2020)

GSE68618 Processing Pipeline

GSE68618 · 11 steps · ChIP-Seq · code_examples

Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. (2017)