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4 results for “zinc finger”

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Zfp697/ZNF697 is an RNA-binding protein that modulates TGF-β1 signaling and hepatic inflammation in liver disease.

Molecular metabolism · 2026 : 102457

Liver diseases driven by metabolic dysfunction, inflammation, and fibrosis such as metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis (MASH), and acute liver injury represent a growing global health burden. The zinc finger protein Zfp697 (ZNF697 in humans) …

PMID 42875003 DOI ↗
Rational design yields RNA-binding zinc finger domains with altered sequence specificity.

RNA (New York, N.Y.) · 2025 · 31(2): 150-163

Targeting and manipulating endogenous RNAs in a sequence-specific manner is essential for both understanding RNA biology and developing RNA-targeting therapeutics. RNA-binding zinc fingers (ZnFs) are excellent candidates as designer proteins to expand the RNA-targeting toolbox, due to their compact size …

PMID 39658359 DOI ↗
Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation.

Molecular cell · 2024 · 84(19): 3826-3842.e8

RNA interactome studies have revealed that hundreds of zinc-finger proteins (ZFPs) are candidate RNA-binding proteins (RBPs), yet their RNA substrates and functional significance remain largely uncharacterized. Here, we present a systematic multi-omics analysis of the DNA- and RNA-binding targets and …

PMID 39303722 DOI ↗
SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes.

Molecular cell · 2016 · 64(2): 282-293

RNA metabolism is controlled by an expanding, yet incomplete, catalog of RNA-binding proteins (RBPs), many of which lack characterized RNA binding domains. Approaches to expand the RBP repertoire to discover non-canonical RBPs are currently needed. Here, HaloTag fusion pull down …

PMID 27720645 DOI ↗

Datasets 11

GSE302600 GSE · GEO

Zfp697/ZNF697 is an RNA-binding protein that modulates TGF-Î²1 2 signaling and hepatic inflammation in liver disease

Mus musculus · GPL30172

GSE277160 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [RNA-seq]

Homo sapiens · GPL24676

GSE249247 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation.

Homo sapiens · GPL24676

GSE86035 GSE · GEO

SONAR discovers RNA binding proteins from analysis of large-scale protein-protein interactomes.

Homo sapiens · GPL20301

GSE277047 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [RBNS]

synthetic construct · GPL34014

GSE72501 GSE · GEO

Ro60-knockout cells

Homo sapiens · GPL16791

GSE268963 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [SLAM-Seq]

Homo sapiens · GPL24676

GSE249245 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [Cut&Run]

Homo sapiens · GPL24676

GSE249246 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [eCLIP]

Homo sapiens · GPL24676

GSE277161 GSE · GEO

Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [Ribo-STAMP cell lines]

Homo sapiens · GPL24676

GSE78959 GSE · GEO

Modeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Cell Model]

Homo sapiens · GPL16791