Datasets (2527)

Mucosal gene expression profiling in patients with inflammatory bowel disease study

A functional genomics predictive network model identifies regulators of inflammatory bowel disease: Mount Sinai Hospital (MSH) Population Specimen Collection and Profiling of Inflammatory Bowel Disease

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia [motor cortex]

RNA sequencing of mice expressing NLS-hTDP-43

ALS implicated protein TDP-43 sustains levels of STMN2 a mediator of motor neuron growth and repair

Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology

Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells (RNA-Seq)

Transcriptional Survey of Ileal-Anal Pouch Immune Cells from Ulcerative Colitis

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy

Loss of canonical splicing factor SRSF1 in hepatocytes results in acute liver injury and regeneration

Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death

In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [eCLIPseq]

In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [RNA-seq]

Function-first proteomic strategies for chemical probe discovery in human cells

Proteomic discovery of chemical probes that perturb protein complexes in human cells

Proteomic discovery of chemical probes that perturb protein complexes in human cells II