Search publications
5 results for “non-coding RNA”
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Mudskipper detects combinatorial RNA binding protein interactions in multiplexed CLIP data.
Cell genomics · 2024 · 4(7): 100603
The uncovering of protein-RNA interactions enables a deeper understanding of RNA processing. Recent multiplexed crosslinking and immunoprecipitation (CLIP) technologies such as antibody-barcoded eCLIP (ABC) dramatically increase the throughput of mapping RNA binding protein (RBP) binding sites. However, multiplex CLIP datasets …
PMID 38955188 DOI ↗
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression.
Molecular cell · 2023 · 83(19): 3421-3437.e11
The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the …
PMID 37751740 DOI ↗
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Nuclear and cytoplasmic poly(A) binding proteins (PABPs) favor distinct transcripts and isoforms.
Nucleic acids research · 2022 · 50(8): 4685-4702
The poly(A)-tail appended to the 3'-end of most eukaryotic transcripts plays a key role in their stability, nuclear transport, and translation. These roles are largely mediated by Poly(A) Binding Proteins (PABPs) that coat poly(A)-tails and interact with various proteins involved …
PMID 35438785 DOI ↗
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Repeat RNA expansion disorders of the nervous system: post-transcriptional mechanisms and therapeutic strategies.
Critical reviews in biochemistry and molecular biology · 2021 · 56(1): 31-53
Dozens of incurable neurological disorders result from expansion of short repeat sequences in both coding and non-coding regions of the transcriptome. Short repeat expansions underlie microsatellite repeat expansion (MRE) disorders including myotonic dystrophy (DM1, CUG<sub>50-3,500</sub> in <i>DMPK</i>; DM2, CCTG<sub>75-11,000</sub> in …
PMID 33172304 DOI ↗
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Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
eLife · 2019 · 8
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either of two ALS-linked …
PMID 30747709 DOI ↗
Datasets 25+
Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation
9544 · GPL11154
Identification of islet-enriched long non-coding RNAs contributing to beta-cell failure in type 2 diabetes
Mus musculus · GPL9250
Transcriptome-wide Profiling of Multiple RNA Modifications Simultaneously at Single-base Resolution
Homo sapiens · GPL15520
High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
Homo sapiens · GPL10999
A transcriptome-wide divergence in protein translation scales with LIN28B expression
Mus musculus · GPL20301
HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons [hnRNPA2B1_small_rnaseq]
Mus musculus · GPL15520
Transcriptomic analysis reveals novel long non-coding RNAs critical for vertebrate development [RNA-Seq]
Homo sapiens · GPL11154
Transcriptomic analysis reveals novel long non-coding RNAs critical for vertebrate development [Affymetrix]
Homo sapiens · GPL6244
Identification of different transcripts that favor the nuclear or cytoplasmic Poly(A) Binding Proteins (PABPs) through RNA immunoprecipitation
Homo sapiens · GPL20301
HNRNPA2B1 regulates alternative RNA processing in the nervous system and accumulates in granules in ALS IPSC-derived motor neurons
Mus musculus · GPL13112
Transcriptomic analysis reveals novel long non-coding RNAs critical for vertebrate development
Homo sapiens · GPL6244
small RNA Seq of Subcutaneous adipose tissue from endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates fed 16 week of high fat high sucrose diet
Mus musculus · GPL17021
Differential LINE-1 retrotransposition in induced pluripotent stem cells between humans and great apes
9598 · GPL11154
Cytoplasmic and nuclear fractionation from HEK293T cells
Homo sapiens · GPL24676
Systematic discovery of RNA binding proteins that control microRNA processing
Homo sapiens · GPL20301
Ribo-STAMP reveals translation status of RNAs bound by PABPN and PABPC
Homo sapiens · GPL24676
MicroRNA expression data from differentiation of human H9 ESCs into definitive endoderm on MEF feeder layers
Homo sapiens · GPL8733
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
Homo sapiens · GPL9052
MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm on MEF feeder layers
Homo sapiens · GPL8733
The LncRNA NEAT1 Nests RNA Binding Proteins and the Microprocessor to Globally Enhance Pri-miRNA Processing
Homo sapiens · GPL20301
MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm in feeder-free conditions
Homo sapiens · GPL8733
Endothelial-AGO1-knockout (EC-AGO1-KO) mice and wild-type (WT) littermates
Mus musculus · GPL11154
Showing first 25 dataset results.
Analyses 5
GSE92602 · 5 steps · RNA-Seq · code_examples
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis. (2020)
GSE54964 · 1 step · GSE · code_examples
Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. (2015)
GSE54966 · 1 step · GSE · code_examples
Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. (2015)
GSE54968 · 4 steps · RNA-Seq · code_examples
Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. (2015)
GSE54969 · 1 step · GSE · code_examples
Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. (2015)