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10 results for “spread”
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Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics.
Cell · 2023 · 186(26): 5690-5704.e20
The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic data revealed that local epidemics varied considerably in the frequency …
PMID 38101407 DOI ↗
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Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes.
Immunity · 2023 · 56(1): 207-223.e8
Tissue-resident memory CD8<sup>+</sup> T (T<sub>RM</sub>) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling infection. T<sub>RM</sub> cells exhibit differences across tissues, but their potential heterogeneity among distinct anatomic compartments …
PMID 36580919 DOI ↗
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Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.
Nature · 2022 · 609(7925): 101-108
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing and/or sequencing capacity, which …
PMID 35798029 DOI ↗
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Implementation of Practical Surface SARS-CoV-2 Surveillance in School Settings.
mSystems · 2022 · 7(4): e0010322
Surface sampling for SARS-CoV-2 RNA detection has shown considerable promise to detect exposure of built environments to infected individuals shedding virus who would not otherwise be detected. Here, we compare two popular sampling media (VTM and SDS) and two popular …
PMID 35703437 DOI ↗
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Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission.
medRxiv : the preprint server for health sciences · 2022
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing/sequencing capacity, which can also …
PMID 35411350 DOI ↗
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The ViReflow pipeline enables user friendly large scale viral consensus genome reconstruction.
Scientific reports · 2022 · 12(1): 5077
Throughout the COVID-19 pandemic, massive sequencing and data sharing efforts enabled the real-time surveillance of novel SARS-CoV-2 strains throughout the world, the results of which provided public health officials with actionable information to prevent the spread of the virus. However, …
PMID 35332213 DOI ↗
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Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
Cell · 2021 · 184(10): 2587-2594.e7
The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has gained a foothold across the world. Using S gene target failure (SGTF) and SARS-CoV-2 genomic sequencing, we investigated the prevalence and dynamics of this variant in …
PMID 33861950 DOI ↗
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S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Proceedings of the National Academy of Sciences of the United States of America · 2021 · 118(11)
Rare genetic mutations result in aggregation and spreading of cognate proteins in neurodegenerative disorders; however, in the absence of mutation (i.e., in the vast majority of "sporadic" cases), mechanisms for protein misfolding/aggregation remain largely unknown. Here, we show environmentally induced …
PMID 33692125 DOI ↗
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Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose.
Journal of virology · 2021 · 95(5)
Zika virus (ZIKV) is a mosquito-borne human pathogen that causes congenital Zika syndrome and neurological symptoms in some adults. There are currently no approved treatments or vaccines for ZIKV, and exploration of therapies targeting host processes could avoid viral development …
PMID 33328307 DOI ↗
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Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
medRxiv : the preprint server for health sciences · 2021
As of January of 2021, the highly transmissible B.1.1.7 variant of SARS-CoV-2, which was first identified in the United Kingdom (U.K.), has gained a strong foothold across the world. Because of the sudden and rapid rise of B.1.1.7, we investigated …
PMID 33564780 DOI ↗
Datasets 25+
Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [PAS-seq]
Homo sapiens · Illumina
Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [RNA-Seq]
Homo sapiens · Illumina
Large-scale tethered screen of RNA-binding proteins reveals novel regulators of poly(A) site selection [eCLIP]
Homo sapiens · Illumina
PUF60-Mediated Splicing Is a Key Driver of Triple Negative Breast Cancer [CRISPR]
GPL24676
PUF60-Mediated Splicing Is a Key Driver of Triple Negative Breast Cancer [eCLIP]
GPL24676
PUF60-Mediated Splicing Is a Key Driver of Triple Negative Breast Cancer [RNA-seq]
GPL24676
Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage
Mus musculus · GPL9115
Loss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons
Mus musculus · GPL5188
Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death
Mus musculus · GPL21103
Aging-linked deterioration of RNA metabolism destabilizes the stress response of neurons [RNA-seq]
Homo sapiens · GPL24676
Aging-linked deterioration of RNA metabolism destabilizes the stress response of neurons [eCLIP-seq]
Mus musculus · GPL24676
Aging-linked deterioration of RNA metabolism destabilizes the stress response of neurons [RNASeq, RiboSeq]
Homo sapiens · GPL24676
CRISPR/Cas9 screening of RNA binding proteins (RBPs) that regulate RUNX1 isoform production
Homo sapiens · GPL20301
Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [RNA-seq]
Homo sapiens · GPL24676
Widespread RNA editing dysregulation in Autism Spectrum Disorders
Homo sapiens · GPL20301
Crosstalk between CRISPR-Cas9 and the human transcriptome
Homo sapiens · GPL20301
Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [RBNS]
synthetic construct · GPL34014
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
Homo sapiens · GPL20301
Disrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43 (Affymetrix)
Mus musculus · GPL13185
Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [SLAM-Seq]
Homo sapiens · GPL24676
Widespread RNA editing dysregulation in Autism Spectrum Disorders [eCLIP-seq]
Homo sapiens · GPL20301
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription [ChIP-Seq]
Homo sapiens · GPL11154
Integrated multi-omics analysis of zinc finger proteins uncovers roles in RNA regulation [Cut&Run]
Homo sapiens · GPL24676
Widespread RNA editing dysregulation in Autism Spectrum Disorders II
Homo sapiens · GPL11154
Showing first 25 dataset results.
Analyses 12
GSE56504 · 2 steps · GSE · code_examples
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. (2022)
GSE55727 · 5 steps · RNA-Seq · code_examples
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020)
GSE107867 · 14 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE107895 · 32 steps · RIP-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE107896 · 14 steps · GSE · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE117776 · 14 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE51264 · 5 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE59288 · 3 steps · RNA-Seq · code_examples
Widespread RNA editing dysregulation in brains from autistic individuals. (2019)
GSE27201 · 1 step · RNA-Seq · code_examples
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)
GSE27218 · 1 step · RNA-Seq · code_examples
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)
GSE27371 · 2 steps · GSE · code_examples
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)
GSE27394 · 1 step · GSE · code_examples
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)